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|Tableting Process: Filling | Tableting Process: Compression | Tableting Process: Ejection||
The process of tableting, tableting cycle remains same though advance technology and machines are invented and world over continues R&D is going for new pharmaceutical machineries. To make a various types of tablets and capsules from compressing powder or granules is one of the oldest methods. As industrialization has taken over, the process of tableting has been applied to an even greater range of products from soaps, to confectionary and pharmaceutical tablets. In pharmaceutical particularly, the tablets tamper proof construction and the absence of any materials superfluous to the dosage: such as the gelatin used to make capsules: has made it an ideal choice.
There are varieties of shapes and forms of tablets in which most common are coated compressed hard tablets, caplets and filled gelatin capsules. The present invention provides for a multi characteristic, bi-layer, capsule like tablet consisting of a blend of one or more excipients, one or more active substances, and in one embodiment a first and second different coloring agent compressed along the longitudinal or axial direction into the shape of a two color capsule. The present invention further provides for covering this compressed multi-colored tablet with a clear coating to provide a solid medicament with the appearance of capsule.
There are following process stages of tableting
In tableting process every stage is very important. In the filling process the exact measurement is used to give accurate weight and dosage for the tablet while filling the bore of the die with granule. The special care must require for the granule being fed into the die is kept free-flowing particularly where difficult materials are being used. Severe damage can be caused if the machine is allowed to run without granule.
Step by step process of Tablet Filling
After completion of filling stage, the second stage is compressing of granule to give the correct hardness. Extra care is essential in this process to protect over compressing. Over compression can damage tooling and machine. If tablet is not compressed properly it can crumble easily and cause poor quality drug with inaccurate dosage. The tablet is first pre compressed to reduce pressure before fully compressing to ensure that all air is removed from granule.
The final stage of Tableting process is ejecting tablet. To avoid damage, careful adjustment of the height to which the lower punch is allowed to rise within the die. The height should be set exactly level with the top edge of the die. If set low, can cause the tablet crush between the take-off plate and the bore of the die and If Set high, the tip of the punch may come into contact with the take-off plate, causing severe damage to both the punch and the machine. • The lower punch begins to rise in the bore of the die lifting the tablet until its base is level with the tap of the die. • The tablet is then pushed aside into the take-off chute by passing under a static blade. • The lower punch then moves to its lowest position ready for filling and the entire cycle is repeated.
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